Sex differences in the effects of gonadectomy on amphetamine-induced rotational behavior in rats.
نویسندگان
چکیده
The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug in each group, thereby controlling for sex differences in the metabolism of amphetamine. Ovariectomy of female rats significantly attenuated amphetamine-induced rotation, whereas castration of males was without effect. The results support the idea that in females, the endogenous gonadal hormones facilitate functional activity in the mesostriatal dopamine system.
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ورودعنوان ژورنال:
- Behavioral and neural biology
دوره 46 3 شماره
صفحات -
تاریخ انتشار 1986